D6 clears away inflammatory chemokines

Putatively Silent Chemokine Receptor D6 CC Chemokines by the Promiscuous Cutting Edge: Scavenging of Inflammatory

Chemokines in inflammatory bowel disease.

C hemokines (chemotactic cytokines) are small (7–10 kDa) heparin binding proteins that govern the migration of circulating leucocytes to the sites of inflammation. Chemokines, currently numbering more than 50, are classified into four supergene families based on cysteine residues: CXC, CC, C, and CX3C chemokines (table 1). Chemokines are distinguished from other cytokines by acting on the G pro...

Chemokines in inflammatory bowel diseases.

Uncontrolled activation of mucosal effector cells has been identified as the main pathogenic mechanism involved in the initiation and perpetuation of mucosal inflammation in inflammatory bowel diseases (IBD). The sustained activation of these cells leads to the aberrant production of various pro-inflammatory mediators, which co-ordinated action amplifies the inflammatory process. In this settin...

Chemokines in idiopathic inflammatory myopathies.

The idiopathic inflammatory myopathies (IIM) represent a heterogeneous group of acquired muscle diseases. The three best-studied subgroups: dermatomyositis (DM), polymyositis (PM), and sporadic inclusion body myositis (IBM), differ considerably both clinically and pathophysiologically. DM is a chiefly humoral endotheliopathy often associated with characteristic skin manifestations. In PM and IB...

Electroporated DNA vaccine clears away multifocal mammary carcinomas in her-2/neu transgenic mice.

The transforming rat Her-2/neu oncogene embedded into the genome of virgin transgenic BALB/c mice (BALB-neuT) provokes the development of an invasive carcinoma in each of their 10 mammary glands. i.m. vaccination with DNA plasmids coding for the extracellular and transmembrane domains of the protein product of the Her-2/neu oncogene started when mice already display multifocal in situ carcinoma...